That kind of behavior my affect performance by prohibiting client retry operations. Additionally, Local Domain Name System (LDNS) resolvers and proxy servers shouldn't use any kind of persistent or IP affinity behavior that prefers a single IP address. Instead, they should provide all results to clients to enable application retries. Local Domain Name System (DNS) resolvers and related firewall applications at users' ISPs and corporate networks should never prune the DNS results lists. For more information about the ports that are used in Microsoft 365, the addresses ranges, and ports that are used in Exchange Online, see Microsoft 365 URLs and IP address ranges. Restricted network access may affect all the Microsoft 365 connectivity. To resolve this issue, open port 443 in the network environment through which the user accesses Outlook and Exchange Online. Network proxy configuration redirects clients to one particular Microsoft 365 IP address range or URL. Outlook Anywhere feature: this feature lets Outlook communicate with Exchange Online.Exchange Autodiscover service: this service sets up Outlook profiles.To enable the following features, port 443 must be open: ![]() The user is located in a restricted network environment that blocks port 443. Local network configuration issues may prevent access to Exchange Online servers, as in the following scenarios. ![]() The user can't create new Outlook profiles.Outlook can't connect to Exchange Online.In Microsoft 365, a user experiences one of the following issues:
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